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KMID : 0370219890330050312
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Yakhak Hoeji
1989 Volume.33 No. 5 p.312 ~ p.318
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Microencapsulation of Propranolol·HCI with Cellulose Acetate Phthalate
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Abstract
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Microcapsule of Propranolol-HC1 with Cellulose Acetate Phthalate (CAP) by coacervationphase separation method was studied. Encapsulation was carried out in the CAP-liquid paraffin-acetone ethanol solvent system. The optimum weight ratio for microencapsulation in the CAP-liquid paraffin-solvent system was 1.32:89.18:9.50 or 1.65:89.42:8.93. The wall thickness of microcapsules increased ac-cording to increasing of CAP concentration, but dissolution rate decreased. The dissolution of propranolol-HCI in simulated gastric and intestinal fluid test solution was completed within 3 min., but T50% of propranolol-HC1 from 1-0.0% CAP-microcapsules were 390 min. and 210 min. respectively. The released amount from 12.5% CAP-microcapsules was 41.8% within 720 min. in simulatd gastric fluid test solution and T50% of those in simulated intestinal fluid test solution was 250 min. .
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